α-Glucosidase inhibition activity and in silico study of 2-(benzo[d][1,3]dioxol-5-yl)-4H-chromen-4-one, a synthetic derivative of flavone.

Bioorganic & Medicinal Chemistry(2019)

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摘要
•BDC, a flavone derivative showed 22.4 fold higher enzyme inhibition than acarbose.•During the enzyme kinetic study BDC showed non-competitive type inhibition.•Molecular association between α-glucosidase and BDC revealed by docking study.•BDC depicteddrug-likeness properties by following all the five rules of Lipinski.•During clinical trials, BDC can be a lead compound for the management of type-2DM.
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关键词
2-(Benzo[d][1,3]dioxol-5-yl)-4H-chromen-4-one (BDC),α-Glucosidase,Anti-diabetic compounds,Non-competitive,Acarbose
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