Impact of disease state on arrhythmic event detection by action potential modelling in cardiac safety pharmacology.
Journal of Pharmacological and Toxicological Methods（2019）
摘要
The present study highlighted the impact of pre-existing cardiovascular disease on arrhythmic event detection suggesting that disease state modelling may need to be incorporated in order to fully realize the goal of the CiPA paradigm in a more accurate predictability of proarrhythmic liabilities of new drug candidate.
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关键词
CiPA initiative,Congestive heart failure,Drug screening,Early afterdepolarization,Human ventricular myocyte,IC50s-Vmin metric,in silico cardiac action potential simulation,Proarrhythmic liability prediction,Safety pharmacology,Hypertrophic cardiomyopathy
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