Separation of Bruton's tyrosine kinase inhibitor atropisomers by supercritical fluid chromatography.
Journal of Chromatography A(2019)
摘要
•Preparative SFC for four groups of BTK inhibitor atropisomers were developed.•Strategies in preparing large quantities of atropisomeric APIs were discussed.•Acetonitrile was used to prevent the degradation leading to methyl boronic ester.
更多查看译文
关键词
Atropisomer,Super/subcritical fluid chromatography,Preparative chromatography,Enantioseparations
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要