A hit deconstruction approach for the discovery of fetal hemoglobin inducers.

Andrew B Benowitz,H Christian Eberl,Connie L Erickson-Miller,Aidan G Gilmartin,Elizabeth R Gore,Monica N Montoute,Zining Wu

Bioorganic & Medicinal Chemistry Letters（2018）

引用 9|浏览20

暂无评分

摘要

•Benzoxaborole compounds can be optimized by deconstruction and reconstruction.•The compounds have been optimized for cellular HbF induction, solubility, and PK.•The optimized compounds inhibit key RNA processing proteins.

查看译文

关键词

Sickle cell anemia,Beta-thalassemia,Fetal hemoglobin,Benzoxaborole,CPSF

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要