Siglec-8 in eosinophilic disorders: receptor expression and targeting using chimeric antibodies.

Fanny Legrand,Yun Cao,Joshua B Wechsler,Xiang Zhu,Nives Zimmermann,Shakuntala Rampertaap, Joseph Monsale,Kimberly Romito,Bradford A Youngblood,Emily C Brock,Michelle A Makiya,Nenad Tomasevic,Christopher Bebbington,Irina Maric,Dean D Metcalfe,Bruce S Bochner,Amy D Klion

Journal of Allergy and Clinical Immunology（2019）

引用 41|浏览19

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摘要

Siglec-8 is highly expressed on blood eosinophils from EO and ND and represents a potential therapeutic target for eosinophilic disorders. Enhanced killing of eosinophils in the presence of IL-5 may lead to increased efficacy in patients with IL-5-driven eosinophilia.

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关键词

Siglec-8,eosinophil,mast cell,soluble receptor,inhibitory receptor,apoptosis,hypereosinophilic syndrome,eosinophilic gastrointestinal disease,mastocytosis,monoclonal antibody

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