Synthesis and computer-aided analysis of the role of linker for novel ligands of the 5-HT 6 serotonin receptor among substituted 1,3,5-triazinylpiperazines.

•Synthesis of a new series of 1,3,5-triazinylpiperazines.•Affinities for receptors: 5-HT6, 5-HT1A and D2 in radioligand binding assays.•Molecular modeling docking studies to 5-HT6 receptor homology model.•SAR studies on the role of linkers for the 5-HT6 receptor affinity.•New lead structure in search for potent 5-HT6 receptor ligands was found.