Lack of improvement in autonomic cardiac tone after sacubitril/valsartan at lower than target doses

Journal of Electrocardiology, pp. 99-100, 2018.

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Autonomic regulation plays a role in the progression of heart failure with reduced ejection fraction (HrEF).Twenty-one HFrEF patients, 60.8 ± 13.1 years, receiving angiotensin inhibition, were replaced by angiotensin receptor-neprilysin inhibitor (ARNI). A 24-hour Holter recording was performed before and after 3 months of the maximum tol...More



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