Efficacy and toxicity of Decitabine in patients with acute myeloid leukemia (AML): A multicenter real-world experience.

Carla Filì,Anna Candoni,Maria Elena Zannier,Jacopo Olivieri,Silvia Imbergamo,Manuela Caizzi,Gianpaolo Nadali,Eros Di Bona,Anna Ermacora,Michele Gottardi,Davide Facchinelli,Rosanna Ciancia,Davide Lazzarotto,Maria Vittoria Dubbini,Gianluca Festini,Filippo Gherlinzoni,Maria Grazia Michieli,Gianpietro Semenzato,Renato Fanin

Leukemia Research（2019）

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摘要

•Decitabine is a valid therapeutic option in AML not suitable for intensive chemotherapy.•The ORR in real-world setting was 33% and median OS in responders was 22.6 mths.•Common toxicities were cytopenia and infections, mainly during the first 4 cycles.

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关键词

Decitabine,Acute myeloid leukemia,Elderly patients

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