Spinal cord injury induced Neuregulin 1 signaling changes in mouse prefrontal cortex and hippocampus

Wei-kang Xue,Wei-jiang Zhao,Xiang-he Meng, Hui-fan Shen,Pei-zhi Huang

Brain Research Bulletin（2019）

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摘要

•SCI can induce activation of astrocytes and microglia in both mouse PFC and HIP.•SCI can alter Nrg1 signaling in both mouse PFC and HIP.•Nrg1 may have a therapeutic role in counteracting SCI-induced brain damage.

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关键词

Spinal cord injury (SCI),Neuregulin 1 (Nrg1),pNeu,pErbB4,Prefrontal cortex (PFC),Hippocampus (HIP),Mouse

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