Local application of MDL28170-loaded PCL film improves functional recovery by preserving survival of motor neurons after traumatic spinal cord injury.

Dongling Shi,Teng He,Weijian Tang,Heyangzi Li,Chao Wang,Mingzhi Zheng,Jue Hu,Xinghui Song,Yuemin Ding,Ying-Ying Chen,Yueliang Shen,Hongfeng Jin,Lin-Lin Wang

Neuroscience Letters（2019）

引用 10|浏览10

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摘要

•PCL film shows no toxic, neuron adhension characteristic.•MDL28170(<50 μM) increases VSC4.1 motor neuronal cell viability in vitro.•MDL28170-loaded PCL film slowly releases MDL28170.•MDL28170-loaded PCL film improves functional recovery in SCI rats.

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关键词

ER,PCL,BSA,H&E,GFAP,GAP43,SCI

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