High UDG and BRCA1 expression is associated with adverse outcome in patients with pemetrexed treated non-small cell lung Cancer

Nooshin Hashemi Sadraei,Yan Feng,Lingling Du,Pingfu Fu,Sulsal Haque,Afshin Dowlati,Jahnavi Gollamudi,Nathan A. Pennell,Tarek Mekhail,Stefanie Avril,Carol Farver,Stanton L. Gerson,Neelesh Sharma

Lung Cancer（2018）

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摘要

•Evaluated expression of UDG and BRCA1 and its correlation with survival outcomes.•High UDG expression was associated with worse progression free survival (PFS).•High UDG and BRCA1 expression was associated with worse PFS and overall survival.•First study evaluating expression of UDG protein by IHC.

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关键词

Uracil DNA glycosylase,UDG,BRCA1,Pemetrexed,Non-small cell lung cancer

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