The allosteric dopamine D1 receptor potentiator, DETQ, ameliorates subchronic phencyclidine-induced object recognition memory deficits and enhances cortical acetylcholine efflux in male humanized D1 receptor knock-in mice.

•The D1 receptor PAM DETQ restored NOR in scPCP-treated hD1 knock-in mice.•The efficacy of DETQ on NOR was blocked by the D1R antagonist, SCH391660.•There was no inverted U-shaped dose response curve or tolerance in the NOR test.•Rivastigmine, with or without DETQ, reversed the deficit in NOR.•DETQ enhances ACh efflux in PFC and HIP in saline- but not scPCP-treated hD1 mice.