Altered blood rheology and impaired pressure-induced cutaneous vasodilation in a mouse model of combined type 2 diabetes and sickle cell trait.

Sarah Skinner,Philippe Connes,Dominique Sigaudo-Roussel,Ming Lo,Kiao Ling Liu,Elie Nader, Audrey Josset-Lamaugarny,Emmanuelle Charrin,Cyril Martin, Camille Romanet-Faes,Mor Diaw,Vincent Pialoux,Bérengère Fromy

Microvascular Research（2019）

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摘要

•Combined type 2 diabetes and sickle cell trait (T2D-SCT) increases blood viscosity.•Combined T2D-SCT decreases red blood cell deformability.•Combined T2D-SCT causes vascular dysfunction.

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关键词

Type 2 diabetes,Sickle cell trait,Microvascular function,Blood viscosity,Red blood cell deformability

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