Inter strand crosslinks in DNA induced in vivo by percutaneous application of sulphur mustard to rats and mice.

Mutation Research/Genetic Toxicology and Environmental Mutagenesis(2018)

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摘要
•Sulphur mustard applied percutaneously rapidly spreads in different organs.•It induces DNA crosslinks in lymphocytes, liver, bone marrow, spleen, colon.•Crosslinks are removed by DNA repair.•More crosslinks are found in rats compared to mice.
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关键词
ICL,SM,SSB,N7-HETEG,N3-HETEA,O6-HETEG,Bis-G,SO,SD
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