Mildly elevated serum total bilirubin is negatively associated with hemoglobin A1c independently of confounding factors among community-dwelling middle-aged and elderly persons.
Journal of circulating biomarkers(2017)
摘要
Abnormally high glycated hemoglobin (Hb) (HbA1c) is significantly associated with oxidative stress and an increased risk of cardiovascular disease (CVD). Serum total bilirubin (T-B) may have a beneficial role in preventing oxidative changes and be a negative risk factor of CVD. Limited information is available on whether serum T-B is an independent confounding factor of HbA1c. The study subjects were 633 men aged 70 ± 9 (mean ± standard deviation (SD)) years and 878 women aged 70 ± 8 years who were enrolled consecutively from among patients aged ≥40 years through a community-based annual check-up process. We evaluated the relationship between various confounding factors including serum T-B and HbA1c in each gender. Multiple linear regression analysis pertaining to HbA1c showed that in men, serum T-B (β = -0.139) as well as waist circumference (β = 0.099), exercise habit (β = 0.137), systolic blood pressure (SBP) (β = 0.076), triglycerides (β = 0.087), and uric acid (β = -0.123) were significantly and independently associated with HbA1c, and in women, serum T-B (β = -0.084) as well as body mass index (β = 0.090), smoking status (β = -0.077), SBP (β = 0.117), diastolic blood pressure (DBP) (β = -0.155), low-density lipoprotein cholesterol (β = 0.074), prevalence of antidyslipidemic medication (β = 0.174), and uric acid (β = 0.090) were also significantly and independently associated with HbA1c. Multivariate-adjusted serum HbA1c levels were significantly high in subjects with the lowest serum T-B levels in both genders. Serum T-B is an independent confounding factor for HbA1c among community-dwelling middle-aged and elderly persons.
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