Positively Selected Sites at HCMV gB Furin Processing Region and Their Effects in Cleavage Efficiency

    Felipe N de Paula
    Felipe N de Paula
    Leonardo G P Ruiz
    Leonardo G P Ruiz
    Antônio S K Braz
    Antônio S K Braz

    Frontiers in microbiology, Volume 8, 2017, Pages 934

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    Keywords:
    furin cleavagegB genotypesglycoprotein Bhuman cytomegalovirusselective pressure

    Abstract:

    Human cytomegalovirus is a ubiquitous infectious agent that affects mainly immunosuppressed, fetuses, and newborns. The virus has several polymorphic regions, in particular in the envelope glycoproteins. The UL55 gene encodes the glycoprotein B that has a variable region, containing a furin cleavage site and according to the variability d...More

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