RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding

Philip Knuckles,Sarah H Carl,Michael Musheev,Christof Niehrs,Alice Wenger,Marc Bühler

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2017）

引用 114|浏览28

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摘要

Microprocessor components Dgcr8 and Drosha associate with transcriptionally active coding and noncoding genes in a Mettl3-dependent manner and, upon temperature stress, relocate to heat-shock genes, where they mark mRNAs for subsequent degradation.

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关键词

Pluripotent stem cells,RNA,RNA decay,RNA modification,Life Sciences,general,Biochemistry,Protein Structure,Membrane Biology,Biological Microscopy

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