Phenolic derivatives from Blaps japanensis and their biological evaluation.

This study was designed to characterize compounds from two thousands of insects of Blaps japanensis. With this purpose, pipajiains A–C (1–3), three novel phenolic derivatives, pipajiains D (4) and E (5), two new natural occurring compounds, and four known substances were isolated thereof. Their structures were identified by spectroscopic methods. Biological activities of all these compounds towards EV71, tuberculosis, COX-2, ROCK1/2, and JAK3 kinases were evaluated.