Effects of breviscapine on amyloid beta 1-42 induced Alzheimer's disease mice: A HPLC-QTOF-MS based plasma metabonomics study.

Hongjun Xia, Lingling Wu,Mengying Chu, Huimin Feng,Chunliang Lu, Qinghe Wang, Minghai He,Xiaoqun Ge

Journal of Chromatography B（2017）

引用 14|浏览2

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摘要

•Metabonomics based research on impact of breviscapine in AD mice is performed.•Metabolic pathways of tryptophan, phospholipid and cholesterol are involved.•Indoleacrylic acid is identified as a new potential biomarker of AD.

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关键词

Breviscapine,Alzheimer’s disease,Mice,Amyloid beta 1-42,Metabonomics,HPLC-QTOF-MS

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