Generation of pure GABAergic neurons by transcription factor programming

Nan Yang,Soham Chanda,Samuele Marro,Yi-Han Ng,Justyna A Janas,Daniel Haag,Cheen Euong Ang,Yunshuo Tang, Quetzal Flores,Moritz Mall,Orly Wapinski, Mavis Li,Henrik Ahlenius,John L Rubenstein,Howard Y Chang, Arturo Alvarez Buylla,Thomas C Südhof,Marius Wernig

Nature Methods（2017）

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摘要

Transient transcription factor expression rapidly induces a homogenous population of mature GABAergic neurons from human pluripotent stem cells, aiding the study of inhibitory neuron function and disease.

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关键词

Neuroscience,Stem-cell differentiation,Life Sciences,general,Biological Techniques,Biological Microscopy,Biomedical Engineering/Biotechnology,Bioinformatics,Proteomics

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