Epidemiology of Invasive Fungal Infections at Two Tertiary Care Neonatal Intensive Care Units Over a 12-Year Period (2000-2011).

We conducted a retrospective review of 168 patients with invasive fungal infections from January 2000 to December 2011 in 2 neonatal intensive care units. Patients with bloodstream infection (BSI, n = 152) were further analyzed. was the most common species overall (47%); however, there was an increase in non- sp from 2006 to 2011. BSI clearance rates were lower in extremely low birth weight infants (77% vs 93%, = .01) and in patients with infections (77% vs 91%, = .01). Clearance rates improved from 2000 to 2005 (70% - 90%) to 2006 to 2011 (86% -100%). Combination antifungal use increased during the later years (73% vs 49%, < .05) and in patients with end-organ dissemination (83% vs 54%, < .05). We concluded that extremely low birth weight infants and infection are factors associated with nonclearance of BSI. Successful clearance of BSI improved in 2006 to 2011, perhaps due to increase in non- species and the use of combination antifungals.