The Clinicopathological Features And Prognosis Of Signet Ring Cell Carcinoma Of The Esophagus: A 10-Year Retrospective Study In China

ObjectivesThe aim of this study was to analyze the clinicopathological features and prognosis of esophageal signet ring cell (SRC) carcinoma in China.MethodsPatients with poorly differentiated adenocarcinoma were identified in two hospitals from January 2006 to June 2016. The patients were divided into three groups according to component of SRCs: SRC >= 50% group, SRC < 50% group and non-SRC poorly differentiated adenocarcinoma group.ResultsFifty-seven patients had carcinoma (SRC >= 50%), and 79 patients had tumors containing < 50% SRCs, and 535 patients was in non-SRC poorly differentiated adenocarcinoma group. There were no significant differences among the three groups in clinicopathological characteristics. Patients in SRC >= 50% group had a lower overall survival rate (at 3-year 37.6% versus71.1%; at 5-year 0% versus 43.3%; p<0.001) compared with the control group. Even survival outcome of patients in SRC < 50% was inferior to that of in control group (at 3-year 53.0% versus71.1%; at 5-year 25.9% versus 43.3%; p<0.001). Female sex, large tumor size and increasing TNM stage were independent prognostic factors for SRC >= 50% esophageal carcinoma patients.ConclusionsThe incidence of esophageal SRC carcinoma is relatively rare and the worst outcome is observed in the SRC >= 50% group. It is necessary to explore new therapeutic modalities to achieve further improvements in the clinical outcome of these patients.