Dihydromyricetin modulates p62 and autophagy crosstalk with the Keap-1/Nrf2 pathway to alleviate ethanol-induced hepatic injury.

Ping Qiu,Yu Dong,Bo Li,Xian-Jie Kang,Chao Gu,Tao Zhu,Yun-Yun Luo,Min-Xia Pang,Wei-Feng Du,Wei-Hong Ge

Toxicology Letters（2017）

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摘要

•Dihydromyricetin efficaciously protects against ethanol-induced liver damage.•Dihydromyricetinpromotesp62-mediated Keap1 inactivation and Nrf2 activation.•Dihydromyricetin inducessufficientautophagy to confirm p62-mediated Keap-1 degradation.

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关键词

ALD,ALP,ALT,ARE,AST,CYP2E1,DAB,DAPI,DMY,DTT,ECL,EDTA,EGTA,ELISA,GSH,H&E,HEPES,HO-1,HPLC,IgG,IL-1β,IL-6,Keap-1,LC3B,LDH,LPS,MDA,NADPH,NF-κB,Nrf2,OCT,PBS,ROS,RIPA,TBARS,TEM

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