Inhibition of the PI3K-Akt-mTOR signaling pathway in T lymphocytes in patients with active tuberculosis.

XueXuan Zhang,TengYi Huang,Ying Wu,WenGuang Peng,HanBin Xie,MeiChen Pan,HuanBin Zhou,BoZhi Cai,YingE Wu

International Journal of Infectious Diseases（2017）

引用 33|浏览5

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摘要

•We mainly study the change of PI3K-Akt-mTOR signaling pathway in T lymphocytes and Treg cells from active TB patients.•The results showed that the mTOR signaling pathway in T lymphocytes and Treg cells is inhibited in active TB patients.•The mTOR pathway is inhibited in active TB patients, which could explain why FoxP3 expanded in patients in partly.

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关键词

PI3K-Akt-mTOR pathway,T lymphocytes,FoxP3+Treg cells,Mycobacterium tuberculosis

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