Erratum to: DeepCpG: accurate prediction of single-cell DNA methylation states using deep learning
Genome biology(2017)
摘要
Recent technological advances have enabled DNA methylation to be assayed at single-cell resolution. However, current protocols are limited by incomplete CpG coverage and hence methods to predict missing methylation states are critical to enable genome-wide analyses. We report DeepCpG, a computational approach based on deep neural networks to predict methylation states in single cells. We evaluate DeepCpG on single-cell methylation data from five cell types generated using alternative sequencing protocols. DeepCpG yields substantially more accurate predictions than previous methods. Additionally, we show that the model parameters can be interpreted, thereby providing insights into how sequence composition affects methylation variability.
更多查看译文
关键词
Artificial neural network,DNA methylation,Deep learning,Epigenetics,Machine learning,Single-cell genomics
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络