Determination of free polysaccharide in Vi glycoconjugate vaccine against typhoid fever.

C Giannelli,E Cappelletti,R Di Benedetto,F Pippi, M Arcuri,V Di Cioccio,L B Martin,A Saul,F Micoli

Journal of Pharmaceutical and Biomedical Analysis（2017）

引用 13|浏览15

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摘要

•A novel quantitative method for free Vi determination in glycoconjugates.•The method works for Vi conjugates with different carrier proteins.•The method is reproducible and allows Vi quantification in diluted samples.•An improved quality control method for reliable Vi conjugates characterization.

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关键词

Free saccharide,Quantification method,Conjugate vaccine,Vi polysaccharide,Salmonella Typhi

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