Interleukin-23 mediates the pathogenesis of LPS/GalN-induced liver injury in mice.

Suxia Bao,Qiang Zhao,Jianming Zheng,Ning Li,Chong Huang,Mingquan Chen,Qi Cheng,Mengqi Zhu,Kangkang Yu,Chenghai Liu,Guangfeng Shi

International Immunopharmacology（2017）

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摘要

•IL-23 was associated with mortality in acute on chronic liver failure patients.•IL-23 neutralizing antibodies attenuated LPS/GalN-induced acute liver injury in mice.•The mechanism of attenuating liver injury involves regulation of Th17-related cytokine and chemokine expression in liver.

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关键词

IL-23,Neutralizing antibody,Th17 cells,Chemokines,Acute hepatic injury

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