Comparative study of two models of combined pulmonary fibrosis and emphysema in mice.

•Two models of CPFE in mice were established using tracheal instillation with bleomycin (BLM) or murine gammaherpesvirus 68 (MHV-68).•The different changes in pathology between BLM and MHV-68 CPFE mice models demonstrated different pathology subtypes of CPFE: macrophage infiltration and apoptosis of type-II lung epithelial cells increased with increasing pathology score for pulmonary fibrosis.