LAT alleviates Th2/Treg imbalance in an OVA-induced allergic asthma mouse model through LAT-PLC-γ1 interaction.

Xi Chen,Xiao-Ming Li,Wen Gu,Di Wang,Yi Chen,Xue-Jun Guo

International Immunopharmacology（2017）

引用 6|浏览6

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摘要

•Th2/Treg imbalance is disrupted in OVA-induced allergic asthma•Site-specific delivery of LAT DNA rectified Th2/Treg imbalance in OVA-induced allergic asthma.•LAT-PLC-γ1 interaction contributes to rectification of Th2/Treg imbalance partly via Raf-MEK-ERK and PI3K-AKT-CREB pathways.

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关键词

LAT,PLC-γ1,Asthma,Th2 cells,Treg cells

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