4-Nonylphenol induces autophagy and attenuates mTOR-p70S6K/4EBP1 signaling by modulating AMPK activation in Sertoli cells.

Peng Duan,Chunhui Hu,Chao Quan,Tingting Yu,Wenting Huang,Wei Chen,Sha Tang,Yuqin Shi,Francis L Martin,Kedi Yang

Toxicology Letters（2017）

引用 58|浏览15

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摘要

•4-Nonylphenol promoted Sertoli cell autophagy and modulated the AMPK-mTOR-p70S6K/4EBP1 signaling pathways in rat testis.•4-Nonylphenol induced autophagy via activating AMPK signaling in Sertoli cells.•4-Nonylphenol inhibited mTOR-p70S6K/4EBP1 activity through AMPK activation in Sertoli cells.

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关键词

4-nonylphenol,Sertoli cells,Autophagy,AMPK,mTOR-p70S6K/4EBP1

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