Fascin2 regulates cisplatin-induced apoptosis in NRK-52E cells.

Xinhui Wang,LaNita Nichols,Elizabeth A Grunz-Borgmann,Zhe Sun,Gerald A Meininger,Timothy L Domeier,Christopher P Baines,Alan R Parrish

Toxicology Letters（2017）

引用 4|浏览30

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摘要

•Cisplatin induces loss of fascin2 protein expression in vitro and in vivo.•Fascin2 is regulated, in part, by α(E)-catenin.•Knockdown of fascin2 increases susceptibility to cisplatin nephrotoxicity in vitro.•Overexpression of fascin2 is renoprotective against cisplatin injury in vitro.

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关键词

α-Catenin,Actin,Aging,Apoptosis,Fascin2,Mitochondria

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