Evaluation of in vivo gene mutation with etoposide using Pig-a and PIGRET assays.

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2016）

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摘要

•We evaluated the mutagenicity of etoposide by Pig-a and PIGRET assays in rats.•Etoposide did not increase Pig-a MFs in both assays in bone marrow cells.•PIGRET assay showed the same results as the Pig-a assay.

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关键词

Pig-a gene,In vivo mutation assay,Genotoxicity

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