The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD.

Jie Yang,Long Qiao,Zhen Zeng,Junnai Wang,Tao Zhu,Juncheng Wei,Mingfu Wu,Shuangmei Ye,Xiaoyuan Huang,Ding Ma,Ronghua Liu,Qinglei Gao

Toxicology Letters（2017）

引用 8|浏览70

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摘要

•PLD affects the proliferation inhibition and apoptosis in HaCaT cells in vitro.•PLD enhances zebrafish skin pigmentation and induces DNA damage in vivo.•PLD damages the HaCaT cells through the ATM/Chk/P53 pathway.•The mechanism explains the HFS induced by PLD.

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关键词

Pegylated liposomal doxorubicin (PLD),HaCaT cell,Apoptosis,Zebrafish

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