The significance of sampling time in therapeutic drug monitoring of clozapine.

M I Jakobsen,J R Larsen, C K Svensson,S S Johansen,K Linnet,J Nielsen,A Fink-Jensen

Acta psychiatrica Scandinavica（2017）

引用 18|浏览7

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摘要

The impact of deviations in clozapine TDM sampling time, within the time span of 10-14 h postdose, seems of minor importance when looking at median percentage differences. However, substantial individual differences were observed, which implies a need to adhere to a fixed sampling time.

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关键词

clozapine,norclozapine,sampling time,serum concentration,therapeutic drug monitoring

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