Trace element and cytokine concentrations in patients with Fibrodysplasia Ossificans Progressiva (FOP): A case control study.

•FOP is a devastating disease with inflammation-related extra bone formation.•Inflammation disturbs trace element metabolism by self-amplifying mechanisms.•Surprisingly, serum concentrations of Cu, Se and Zn are normal in FOP patients.•Proinflammatory cytokine and Activin A levels are also undisturbed in FOP.•Our findings exclude ongoing systemic chronic inflammations in FOP patients.