True rifampicin resistance missed by the MGIT: prevalence of this pheno/genotype in the UK and Ireland after 18 month surveillance.

X Gonzalo, P Claxton,T Brown,L Montgomery,M Fitzgibbon,I Laurenson,F Drobniewski

Clinical Microbiology and Infection（2017）

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摘要

Rifampicin resistance is missed by the MGIT system. In the UK and Ireland the prevalence of these strains is low. The introduction of routine molecular testing would detect false susceptibility. Further research is needed to ascertain the role of these strains in clinical failure and their prevalence in other settings.

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关键词

Drug susceptibility testing,Genotypic dst,Line probe assay,Mycobacterium tuberculosis,Proportion method,Resistance ratio,Rifampicin,rpoB sequencing,Very major error

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