Pyruvate dehydrogenase has a major role in mast cell function, and its activity is regulated by mitochondrial microphthalmia transcription factor.

Israa Sharkia,Tal Hadad Erlich,Nadine Landolina,Miri Assayag,Alex Motzik,Inbal Rachmin,Gillian Kay,Ziv Porat,Sagi Tshori,Neville Berkman,Francesca Levi-Schaffer,Ehud Razin

Journal of Allergy and Clinical Immunology（2017）

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摘要

The association of mitochondrial MITF with PDH emerges as an important regulator of mast cell function. Our findings indicate that PDH could arise as a new target for the manipulation of allergic diseases.

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关键词

Allergy,mast cells,degranulation,cytokines,pyruvate dehydrogenase,microphthalmia transcription factor,asthma,mitochondria

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