Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR–Cas9 library

Shiyou Zhu,Wei Li,Jingze Liu,Chen-Hao Chen,Qi Liao,Ping Xu,Han Xu,Tengfei Xiao,Zhongzheng Cao,Jingyu Peng,Pengfei Yuan,Myles Brown,Xiaole Shirley Liu,Wensheng Wei

NATURE BIOTECHNOLOGY（2016）

引用 391|浏览32

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摘要

Long non-coding RNAs are identified using a high-throughput paired-guide RNA genomic deletion screen.

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关键词

CRISPR-Cas9 genome editing,High-throughput screening,Mutagenesis,Life Sciences,general,Biotechnology,Biomedicine,Agriculture,Biomedical Engineering/Biotechnology,Bioinformatics

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