MiR-222 promotes drug-resistance of breast cancer cells to adriamycin via modulation of PTEN/Akt/FOXO1 pathway

Hongyu Shen,Dandan Wang,Liangpeng Li,Sujin Yang,Xiu Chen,Siying Zhou,Shanliang Zhong,Jianhua Zhao,Jinhai Tang

Gene（2017）

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摘要

•The expression of miR-222 is negatively correlated with FOXO1 expression in breast cancer cells.•PTEN/Akt/FOXO1 pathway plays an important role in ADR-resistance of breast cancer.•Inhibition of miR-222 could reverse the ADR-resistance and improve the prognosis of breast cancer patients.

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关键词

ADR,miRNA,UTR,PTEN,PIP3,PIP2,IC50,FBS,NC,PBS,RT-qPCR,MTT,DMSO,KEGG,RIPA,SDS-PAGE,PVDF,ECL,TCGA,SD,NSCLC

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