Glucose: archetypal biomarker in diabetes diagnosis, clinical management and research.
BIOMARKERS IN MEDICINE(2016)
摘要
The clinical utility of diabetes biomarkers can be considered in terms of diagnosis, management and prediction of long-term vascular complications. Glucose satisfies all of these requirements. Thresholds of hyperglycemia diagnostic of diabetes reflect inflections that confer a risk of developing long-term microvascular complications. Degrees of hyperglycemia (impaired fasting glucose, impaired glucose tolerance) that lie below the diagnostic threshold for diabetes identify individuals at risk of progression to diabetes and/or development of atherothrombotic cardiovascular disease. Self-measured glucose levels usefully complement hemoglobin A(1c) levels to guide daily management decisions. Continuous glucose monitoring provides detailed real-time data that is of value in clinical decision making, assessing response to new diabetes drugs and the development of closed-loop artificial pancreas technology.
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关键词
biomarker,cardiovascular disease,continuous glucose monitoring,diabetes mellitus,diabetic complications,diagnosis,glucose,glycated hemoglobin,impaired fasting glucose,impaired glucose tolerance,microvascular complications
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