Inhibition of phosphodiesterase 3, 4, and 5 induces endolymphatic hydrops in mouse inner ear, as evaluated with repeated 9.4T MRI.

Eva Degerman,Rene In 't Zandt,Annki Pålbrink,Lena Eliasson,Per Cayé-Thomasen,Måns Magnusson

ACTA OTO-LARYNGOLOGICA（2017）

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摘要

PDE3, PDE4, as well as PDE5 inhibitors resulted in the development of endolymphatic hydrops. Furthermore, PDE3B, PDE4D, and some related signaling components were shown to be expressed in the human saccule.

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Aquaporin2,Ménière’s disease,cilostamide,cochlea,rolipram,sildenafil

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