Deep hypothermia-enhanced autophagy protects PC12 cells against oxygen glucose deprivation via a mitochondrial pathway.

Dang Tang, Cheng Wang,Yongjun Gao,Jun Pu,Jiang Long,Wei Xu

Neuroscience Letters（2016）

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摘要

•Deep hypothermia protects against OGD-induced cell injury.•Neuroprotective effects of deep hypothermia are associated with suppressing mitochondrial apoptotic pathway.•Deep hypothermia-enhanced autophagy plays a protective role via a mitochondrial pathway.

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关键词

DHCA,DH,OGD,I/R,CytC,PARP,PC12,MMP,3-MA,LC3

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