A rapid and sensitive UHPLC-MS/MS assay for the determination of trelagliptin in rat plasma and its application to a pharmacokinetic study.

Xiao-Xia Hu,Tian Lan,Zhe Chen,Cheng-Cheng Yang,Peng-Fei Tang,Ling-Jing Yuan,Guo-Xin Hu,Jian-Ping Cai

Journal of Chromatography B（2016）

引用 10|浏览5

暂无评分

摘要

•It is the first time to report the determination of trelagliptin in rat plasma.•This UHPLC–MS/MS method is simple, rapid and sensitive.•The method has been successfully applied to pharmacokinetic.•The absolute bioavailability of trelagliptin was reported as high as 57.3%.

查看译文

关键词

Trelagliptin,UHPLC–MS/MS,Pharmacokinetics,Rat plasma

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要