Natriuretic Peptide Receptor-C is Up-Regulated in the Intima of Advanced Carotid Artery Atherosclerosis.

Mohamed A Zayed, Scott D Harring,Dana R Abendschein,Chandu Vemuri, Dongsi Lu,Lisa Detering,Yongjian Liu,Pamela K Woodard

Journal of medical & surgical pathology（2016）

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摘要

These findings demonstrate significant NPR-C expression in the intima of advanced carotid artery plaques. Furthermore, NPR-C expression was higher in vulnerable carotid plaque intimal regions, and correlate with features of advanced disease. Our findings suggest that NPR-C may serve as a potential biomarker for carotid plaque vulnerability and progression, in patients with advanced carotid artery occlusive disease.

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关键词

Arterial intima,Atherosclerosis,Carotid,Natriuretic peptide receptor-C,Plaque biomarker,Plaque vulnerability,Stroke

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