EGFR regulates iron homeostasis to promote cancer growth through redistribution of transferrin receptor 1.

Biao Wang,Jiqin Zhang,Fei Song,Mi Tian,Bizhi Shi,Hua Jiang,Wen Xu,Hai Wang,Min Zhou,Xiaorong Pan,Jianren Gu,Shengli Yang,Liyan Jiang,Zonghai Li

Cancer Letters（2016）

引用 49|浏览13

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摘要

•EGFR interacts with TfR1 in a kinase-dependent manner.•EGFR kinase activity maintains cell surface TfR1 expression.•EGFR kinase activity affects cellular iron homeostasis through TfR1.•EGFR activation is positively correlated with membrane TfR1 and iron expression in NSCLC patients.

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关键词

EGFR,TfR1,Iron homeostasis,Tyrosine phosphorylation

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