The efficient elimination of solid tumor cells by EGFR-specific and HER2-specific scFv-SNAP fusion proteins conjugated to benzylguanine-modified auristatin F.

Mira Woitok,Diana Klose,Judith Niesen,Wolfgang Richter,Muhammad Abbas,Christoph Stein,Rolf Fendel,Magdalena Bialon,Christiane Püttmann,Rainer Fischer,Stefan Barth,Katharina Kolberg

Cancer Letters（2016）

引用 34|浏览15

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摘要

•Generation of site specific conjugated antibody drug conjugates with auristatin F.•Use of SNAP-tag to couple auristatin to HER2-/EGFR-specific scFv-SNAP fusion proteins.•Specific binding and internalization to HER2+ and EGFR+ tumor cell lines.•Induction of cell cycle arrest and apoptosis demonstrated in vitro.

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关键词

SNAP-tag technology,Auristatin,EGFR,HER2,ADC

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