Effect of Circulation Parameters on Functional Status of HepaRG Spheroids Cultured in Microbioreactor

O. V. Semenova, V. A. Petrov,T. N. Gerasimenko,A. V. Aleksandrova,O. A. Burmistrova,A. A. Khutornenko,A. I. Osipyants,A. A. Poloznikov,D. A. Sakharov

Bulletin of experimental biology and medicine（2016）

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摘要

We studied the relationship between microcirculation parameters and functional status of HepaRG cells in spheroids and chose an optimal regimen within the physiologically permissible limits of mechanical impact for the cells that maintains the expression of functional genes of the liver.

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关键词

HepaRG spheroids,liver-on-a-chip,microcirculation

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