The antileishmanial drug miltefosine (Impavido(®)) causes oxidation of DNA bases, apoptosis, and necrosis in mammalian cells.

Patrícia Valéria Castelo Branco,Rossy-Eric Pereira Soares,Luís Cláudio Lima de Jesus,Vanessa Ribeiro Moreira,Hugo José Alves,Marta Regina de Castro Belfort,Vera Lucia Maciel Silva,Silma Regina Ferreira Pereira

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2016）

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摘要

•The action of anti leishmania miltefosine with the genetic material is revealed.•This drug has genotoxic and mutagenic effect.•Cell death by apoptosis and necrosis were also checked.

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关键词

Genotoxicity,Comet assay,Micronucleus test

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