Alterations in the intestine of Patagonian silverside (Odontesthes hatcheri) exposed to microcystin-LR: Changes in the glycosylation pattern of the intestinal wall and inhibition of multidrug resistance proteins efflux activity.
Aquatic Toxicology(2016)
摘要
O. hatcheri received MCLR through the diet for lectin-histochemistry studies.MCLR changed the intestinal epithelium glycoconjugates composition and distribution.MCLR transport was studied in ex vivo O. hatcheris intestine preparations.MCLR inhibited apical and basolateral transport of Abcc substrates (DNP-SG, calcein).MCLR would be excreted and/or absorbed to the blood by Abcc proteins.
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关键词
ABC,Abcb1,Abcc,Bcrp,BSA,calcein-AM,CDNB,ConA-FITC,DBA,DNP-SG,DTT,GSH,GST,GS-X pumps,MC,MCLR,MXR,Oatps,pNPP,PP,SPE,WGA
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