Benzolamide improves oxygenation and reduces acute mountain sickness during a high-altitude trek and has fewer side effects than acetazolamide at sea level

    Pharmacology research & perspectives, Volume 4, Issue 3, 2016.

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    Keywords:
    Acetazolamideacute mountain sicknessbenzolamidecarbonic anhydrase inhibitorhigh altitudeMore(3+)

    Abstract:

    Acetazolamide is the standard carbonic anhydrase (CA) inhibitor used for acute mountain sickness (AMS), however some of its undesirable effects are related to intracellular penetrance into many tissues, including across the blood-brain barrier. Benzolamide is a much more hydrophilic inhibitor, which nonetheless retains a strong renal acti...More

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